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Karin Jurkat-Rott Selected Research

Hypokalemic Periodic Paralysis (Periodic Paralysis, Hypokalemic)

7/2019Strength and muscle structure preserved during long-term therapy in a patient with hypokalemic periodic paralysis (Cav1.1-R1239G).
10/2018NaV1.4 DI-S4 periodic paralysis mutation R222W enhances inactivation and promotes leak current to attenuate action potentials and depolarize muscle fibers.
1/2014Domain III S4 in closed-state fast inactivation: insights from a periodic paralysis mutation.
11/2013Hypokalemic periodic paralysis induced by thymic hyperplasia and relieved by thymectomy.
12/20113 Tesla sodium inversion recovery magnetic resonance imaging allows for improved visualization of intracellular sodium content changes in muscular channelopathies.
3/2009K+-dependent paradoxical membrane depolarization and Na+ overload, major and reversible contributors to weakness by ion channel leaks.
1/2008Progressive muscle atrophy with hypokalemic periodic paralysis and calcium channel mutation.
7/2007Gating of the HypoPP-1 mutations: II. Effects of a calcium-channel agonist BayK 8644.
7/2007Do hyperpolarization-induced proton currents contribute to the pathogenesis of hypokalemic periodic paralysis, a voltage sensor channelopathy?
11/2006Paroxysmal muscle weakness: the familial periodic paralyses.
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Karin Jurkat-Rott Research Topics

Disease

12Channelopathies
09/2017 - 01/2002
11Hypokalemic Periodic Paralysis (Periodic Paralysis, Hypokalemic)
07/2019 - 04/2002
10Paralysis (Palsy)
07/2019 - 04/2002
7Myotonia
10/2020 - 04/2012
6Edema (Dropsy)
07/2019 - 12/2011
5Malignant Hyperthermia
01/2021 - 02/2003
3Myotonia Congenita (Thomsen Disease)
10/2020 - 08/2012
3Migraine Disorders (Migraine)
01/2018 - 10/2005
3Epilepsy (Aura)
12/2015 - 01/2005
3Myotonic Disorders (Paramyotonia Congenita)
11/2015 - 08/2006
3Muscle Weakness
11/2015 - 08/2006
3Contracture
01/2014 - 09/2005
2Migraine with Aura (Familial Hemiplegic Migraine)
01/2018 - 10/2005
2Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
01/2017 - 05/2012
2Hyperkalemic Periodic Paralysis
11/2015 - 07/2012
2Epileptic Syndromes
12/2014 - 01/2005
2Myotonic Dystrophy (Dystrophia Myotonica)
10/2012 - 10/2003
2Muscle Cramp (Cramp)
04/2012 - 09/2005
1Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
11/2017
1Potassium aggravated myotonia
09/2017
1Muscular Diseases (Myopathy)
02/2017
1Tremor (Tremors)
12/2015
1Hypocalcemia
11/2015
1Febrile Seizures (Febrile Seizure)
12/2014
1Fever (Fevers)
12/2014
1Neoplasms (Cancer)
05/2014
1Myasthenia Gravis
11/2013
1Hypokalemia
11/2013
1Thymus Hyperplasia
11/2013
1Fatigue
12/2012
1Andersen Syndrome
02/2012
1Muscular Atrophy (Muscle Atrophy)
01/2008
1Hyperkalemia
09/2005
1Fasciculation (Fasciculations)
09/2005
1Rhabdomyolysis
09/2005
1Hyperthermia
09/2005
1Generalized Epilepsy
01/2005
1Juvenile Myoclonic Epilepsy
01/2005
1familial type 2 Hemiplegic migraine
09/2004

Drug/Important Bio-Agent (IBA)

12SodiumIBA
07/2019 - 08/2006
8PotassiumIBA
10/2020 - 11/2013
6Sodium Channels (Sodium Channel)IBA
02/2017 - 04/2002
6Ion Channels (Ion Channel)IBA
10/2016 - 01/2002
6Calcium Channels (Calcium Channel)IBA
12/2013 - 04/2002
5ChloridesIBA
10/2020 - 01/2016
5Proteins (Proteins, Gene)FDA Link
12/2014 - 01/2002
3Chloride Channels (Chloride Channel)IBA
01/2020 - 08/2012
3Eplerenone (Inspra)FDA LinkGeneric
01/2017 - 05/2012
3CalciumIBA
04/2014 - 02/2003
2Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA
01/2021 - 11/2017
2CationsIBA
11/2015 - 03/2009
2Caffeine (No Doz)FDA LinkGeneric
01/2014 - 09/2005
2Protons (Proton)IBA
07/2012 - 07/2007
2Mexiletine (Mexitil)FDA LinkGeneric
08/2006 - 04/2005
2Adenosine Triphosphatases (ATPase)IBA
10/2005 - 09/2004
1Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA
10/2020
1paxillineIBA
01/2020
19-anthroic acidIBA
01/2020
1Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA
01/2020
1Spironolactone (Aldactone)FDA LinkGeneric
07/2019
1Voltage-Gated Sodium ChannelsIBA
01/2018
1DiureticsIBA
01/2017
1GlucocorticoidsIBA
01/2017
1coenzyme Q10 (CoQ10)IBA
10/2016
1Mineralocorticoid Receptor AntagonistsIBA
10/2016
1ChlorineIBA
01/2016
1Ammonium CompoundsIBA
12/2015
1IonsIBA
12/2015
1Divalent CationsIBA
11/2015
1MagnesiumIBA
11/2015
1Syntaxin 1IBA
12/2014
1Arginine (L-Arginine)FDA Link
04/2014
1Halothane (Fluothane)FDA Link
01/2014
1Cysteine (L-Cysteine)FDA Link
01/2014
1AutoantibodiesIBA
11/2013
1Keratin-5 (Keratin 5)IBA
11/2013
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
11/2013
1Cholinergic ReceptorsIBA
11/2013
1LDL Receptors (LDL Receptor)IBA
11/2013
1Hydrocortisone (Cortisol)FDA LinkGeneric
11/2013
1Thyroid HormonesIBA
11/2013
1Adrenocorticotropic Hormone (ACTH)FDA Link
11/2013
1Adrenal Cortex Hormones (Corticosteroids)IBA
10/2013
1CalpainIBA
12/2012
1Peptide Hydrolases (Proteases)FDA Link
12/2012
1HydrogenIBA
07/2012
1Lidocaine (Xylocaine)FDA LinkGeneric
04/2012
1Inwardly Rectifying Potassium Channels (Inward Rectifier Potassium Channels)IBA
02/2012
1trans-sodium crocetinate (crocetin)IBA
12/2011
1L-Type Calcium Channels (Dihydropyridine Receptor)IBA
07/2007
1N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA
09/2005
1RNA (Ribonucleic Acid)IBA
08/2005
1AntibodiesIBA
08/2005
1Immunoglobulin E (IgE)IBA
01/2005
1Ligand-Gated Ion ChannelsIBA
01/2005

Therapy/Procedure

3Therapeutics
01/2020 - 08/2006
1Physical Therapy Modalities (Physical Therapy Technique)
07/2019
1General Anesthesia
01/2014
1Thymectomy
11/2013
1Aftercare (After-Treatment)
08/2006